Delineation of an Isodicentric Y Chromosome in a Mosaic 45,X/46,X,idic(Y)(qter-p11.3:: p11.3-qter) Fetus by SRY Sequencing, G-banding, FISH, SKY and Study of Distribution in Different Tissues

Delineation of an Isodicentric Y Chromosome in a Mosaic 45,X/46,X,idic(Y)(qter-p11.3:: p11.3-qter) Fetus by SRY Sequencing, G-banding, FISH, SKY and Study of Distribution in Different Tissues

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Many factors such as genetic, developmental and hormonal are involved in mammalian sex determination.The faber-castell tamitio rollerball pen relative importance and the mutual interactions among those factors are obscure.Study of cytogenetic mosaicism involving sex chromosomes may help to further unravel the mysterious process.We report a fetus with a mosaic karyotype, 45,X/46,X,idic(Y)(qter-p11.

3::p11.3-qter), with unambiguous male external genitalia and a defect in the interventricular septum of the heart.Genotype of this fetus xbox series x yoke was extensively studied by technologies including sequencing of SRY (sex-determining region on the Y chromosome) gene, G-banding, FISH (fluorescence in situ hybridization) and SKY (spectral karyotyping).A markedly higher percentage of Y-containing cells was observed in the gonads (55%) than in the amniotic fluid (17%) and placental villi (11%), which was considered to be the major reason why the fetus did not have ambiguous genitalia.